Search results for "Early phase"

Effects of a short-term resistance program using elastic bands versus weight machines for sedentary middle-aged women.

2008

This study was designed to determine whether different effects on functional capacity and body composition were produced by using different devices (elastic bands (EBs) versus weight machines (WMs)) with the same resistance training program. Forty-five healthy sedentary middle-aged women volunteers were chosen and randomly assigned to 1 of 3 groups: 21 subjects trained using EBs (EBG), 14 in trained using WMs (WMG), and 10 were controls (CG). Both exercise groups trained with a periodized muscular endurance program twice a week for 10 weeks, with a total of 6 exercises per session for the major muscle groups. Exercise intensity was equalized by jointly monitoring the same targeted number of…

A brief guide to performing pharmacological studies in vitro: Reflections from the EORTC-PAMM Course “Preclinical and Early-phase Clinical Pharmacolo…

2019

One aim of cell-based in vitro assays is to identify the best drug candidate to develop using the best tumor cell model. This is challenging in every anticancer drug discovery process. Briefly, we summarize the parameters to be taken into account when performing in vitro cell assays, in order to obtain reliable and reproducible results, which was fundamentally discussed by lecturers at the educational course on preclinical and early-phase clinical pharmacology studies, at the 40th Winter Meeting of the Pharmacology and Molecular Mechanisms Group of the European Organization for Research and Treatment of Cancer. Moreover, specific cellular sensitivity tests are described. In addition to mono…

Pottery decoration in the Neolithic of Kaf Taht el-Ghar (Tetouan, Morocco). AGRIWESTMED Works 2012

2021

Presentamos el estudio de los restos cerámicos de la fase neolítica de Kaf Taht el-Ghar (Mechrouha, Tetuán, Marruecos), enfocado principalmente en el análisis de técnicas y patrones decorativos. Ello cuenta con el interés añadido de corresponder, en su fase antigua, a las cerámicas asociadas a las primeras evidencias de agricultura y ganadería en el Magreb Occidental, encuadradas en el tercer cuarto del VI milenio cal AC. En dichas decoraciones dominan impresiones variadas, en particular las realizadas con concha estriada y lisa, peine y de cypraea. El uso de tales técnicas podría incluir estas primeras producciones cerámicas dentro del mundo impresso-cardial de la Europa mediterránea centr…

Burkitt lymphoma with a granulomatous reaction: an M1/Th1‐polarised microenvironment is associated with controlled growth and spontaneous regression

2021

Aims Burkitt lymphoma (BL) is an aggressive B-cell lymphoma that, in some instances, may show a granulomatous reaction associated with a favourable prognosis and occasional spontaneous regression. In the present study, we aimed to define the tumour microenvironment (TME) in four such cases, two of which regressed spontaneously. Methods and results All cases showed aggregates of tumour cells with the typical morphology, molecular cytogenetics and immunophenotype of BL surrounded by a florid epithelioid granulomatous reaction. All four cases were Epstein-Barr virus (EBV)-positive with type I latency. Investigation of the TME showed similar features in all four cases. The analysis revealed a p…

Agency displays in stories of drunk driving: Subjectivity, authorship, and reflectivity

2012

This study examined 30 stories of drunk driving (DD) recounted by repeat offenders in the early phase of a court-mandated counseling program. The focus of analysis was on displays of agency in the narrators’ portrayal of themselves as protagonists in the stories. The expressions of subjectivity, authorship, and reflectivity were considered as constructors of agency positions. In the analysis of the videotaped and transcribed stories, five story types of agency were found. They displayed the narrator-protagonists’ agency positions as either unconcerned, weak, egotistical, akratic, or disowned. The quality of telling is viewed as expressing the narrators’ problematic agency positions, readine…

Negative emotional state modulates visual working memory in the late consolidation phase

2020

Although a considerable literature has grown up around the interactions between emotional state and visual working memory (VWM) performance, the mechanism underlying the impact of the negative emotional state on VWM remains unclear. The present study aimed to test whether the influence of emotional state is related to the early phase or late phase of VWM consolidation process. Across three experiments, we found that the negative emotional state did not affect VWM performance when the presentation time of stimuli was short. However, when the presentation time was long, the negative emotional state increased the VWM precision and reduced the VWM number. According to the two-phase model propos…

Meibomian glands structure in daily disposable soft contact lens wearers: a one‐year follow‐up study

2020

Purpose To assess the impact of daily disposable soft contact lenses on meibomian gland morphology over a period of 12 months. Methods Forty-one subjects (33 experienced and 8 neophytes) were fitted with either silicone-hydrogel or hydrogel daily contact lenses. The study protocol included four visits: baseline, day-2 for contact lens fit and follow-up measurements, as well as after 6 and 12 months of lens wear. Non-contact infrared meibography images were acquired with Keratograph 5M topographer (www.oculus.de) and analysed with an automated method, which objectively estimates the area of gland atrophy, gland length and width, number of glands and gland irregularity. Protocol at follow-up …

A randomised clinical trial to evaluate the acceptability and efficacy of an early phase, online, guided augmentation of outpatient care for adults w…

2019

AbstractBackgroundOutpatient interventions for adult anorexia nervosa typically have a modest impact on weight and eating disorder symptomatology. This study examined whether adding a brief online intervention focused on enhancing motivation to change and the development of a recovery identity (RecoveryMANTRA) would improve outcomes in adults with anorexia nervosa.MethodsParticipants with anorexia nervosa (n= 187) were recruited from 22 eating disorder outpatient services throughout the UK. They were randomised to receiving RecoveryMANTRA in addition to treatment as usual (TAU) (n= 99; experimental group) or TAU only (n= 88; control group). Outcomes were measured at end-of-intervention (6 w…

Bronze of the Living, Bronze of the Dead

2023

In the area considered here, the funerary goods found in burials dating from the Late MBA to the beginning of the LBA (Bz C2 to Ha A1) are particularly rich, with a variety of bronze objects such as ornaments, clothing accessories, tools and weapons. Contemporary settlements only occasionally provide “lost” metal objects and deposits on land or in rivers remain rare. Is it possible from the objects found in excavated contexts (burials, settlements, hoards) alone to evaluate the bronze that circulated during the Late Bronze Age? How representative are the objects in these contexts of bronze production and do they really indicate the metal held within economic exchange networks? How can we de…

2020

Background: An adequate level of muscular fitness is related to occupational performance in military personnel, including pilots flying high performance aircraft. The aim of this study was to describe the baseline level and the change in muscular fitness between the first and the second years of the Air Force Academy among fighter pilot cadets. Methods: The muscular strength and endurance test results of 182 male fighter pilot cadets were analyzed during their first year in the Air Force Academy and one year after. Maximal isometric strength tests included trunk flexion, trunk extension and bilateral leg extension tests, whereas muscle endurance was measured with modified a sit-up test and …